FO - 10th International Conference
Medical Applications of Novel Biomaterials and Nano-biotechnology

Co-Chairs:
Luigi AMBROSIO, University of Naples "Federico II", Italy
Paul DUCHEYNE, Penn University, USA
Teruo OKANO, Tokyo Women's Medical University, Japan
Xingdong ZHANG, Sichuan University, China

Programme Chair:
Aldo R. BOCCACCINI, University of Erlangen-Nuremberg, Germany

Members:
Serena BEST, University of Cambridge, UK
Marc BOHNER, RMS Foundation, Switzerland
Yilin CAO, Shanghai 2 Medical University, China
Jiang CHANG, Shanghai Institute of Ceramics, CAS, China
Jinwoo CHEON, Yonsey University, Korea
Smadar COHEN, Ben-Gurion University of the Negev, Israel
Dermot DIAMOND, Dublin City University, Ireland
Peter FRATZL, Max-Planck Institute of Colloids and Interfaces, Germany
Paul GATENHOLM, Chalmers University, Sweden
Vasif HASIRCI, Middle East Technical University, Turkey
Larry HENCH, Florida Inst.of Technology & Univ.of Central Florida, USA
Kazuhiko ISHIHARA, University of Tokyo, Japan
Esmaiel JABBARI, University of South Carolina, USA
John A. JANSEN, Radboud University, Netherlands
Ali KHADEMHOSSEINI, Harvard - MIT, USA
Michael KHOR, Nanyang Technological University, Singapore
Robert LANGER, MIT, USA
Cato LAURENCIN, University of Connecticut, USA
Andreas LENDLEIN, Helmholtz-Zentrum Geesthacht, Germany
Leandro LORENZELLI, FBK - Bruno Kessler Foundation, Italy
Dan LUO, Cornell University, USA
Antonio MASTINO, CNR-IFT, Italy
Patrick T. MATHER, Syracuse Biomaterials Institute, USA
Hamish MEFFIN, University of Melbourne, Australia
Silvestro MICERA, EPFL, Switzerland
Antonios G. MIKOS, Rice University, USA
Yannis F. MISSIRLIS, University of Patras, Greece
Roger Jagdish NARAYAN, North Carolina State University, USA
Showan N. NAZHAT, McGill University, Canada
Jun OHTA, Nara Institute of Science & Technology, Japan
Chikara OHTSUKI, Nagoya University, Japan
Akiyoshi OSAKA, Okayama University, Japan
Abhay PANDIT, National University of Ireland, Ireland
Heinz REDL, Ludwig Boltzmann Institute, Austria
Philippe RENAUD, EPFL, Switzerland
Christian REY, CIRIMAT-ENSIACET, France
Alexander SEIFALIAN, University College London, UK
Jukka SEPPALA, Aalto University, Finland
Gabriel A. SILVA, University of California, San Diego, USA
Molly STEVENS, Imperial College London, UK
Min WANG, University of Hong Kong, Hong Kong
Thomas J. WEBSTER, Northeastern University, USA
Hanein YAEL, Tel Aviv University, Israel
Ke YANG, Institute of Metal Research, CAS, China
Jackie YING, Institute of Bioengineering and Nanotechnology, Singapore
Nobuhiko YUI, Tokyo Medical and Dental University, Japan
Zhiyuan ZHONG, Soochow University, China
Christian A. ZORMAN, Case Western Reserve University, USA
Polina ANIKEEVA, MIT, USA
Laura BALLERINI, University of Trieste, Italy
Maria BASSIL, Lebanese University, Lebanon
Serena BEST, University of Cambridge, UK
Aldo R. BOCCACCINI, University of Erlangen-Nuremberg, Germany
Herbert BOUSACK, Forschungszentrum Jülich GmbH, Germany
David BRAYDEN, University College of Dublin, Ireland
Brian DERBY, The University of Manchester, UK
Noam ELIAZ, Tel Aviv University, Israel
Yasuhiko IWASAKI, Kansai University, Japan
Esmaiel JABBARI, University of South Carolina, USA
Tao JIANG, University of Connecticut, USA
Cato LAURENCIN, University of Connecticut, USA
Marcelle MACHLUF, Technion, Israel
Mizuo MAEDA, RIKEN, Japan
Roger Jagdish NARAYAN, UNC/NCSU Joint Dept.of Biomedical Eng., USA
Jun OHTA, Nara Institute of Science & Technology, Japan
Christelle PRINZ, Lund University, Sweden
Mario I. ROMERO-ORTEGA, University ofTexas at Arlington, USA
Sirinrath SIRIVISOOT, King Mongkut's University of Technology Thonburi, Thailand
Micha SPIRA, The Hebrew University of Jerusalem, Israel
André STUDART, ETH Zurich, Switzerland
Hasan ULUDAG, University of Alberta, Canada
Thomas J. WEBSTER, Northeastern University, USA
Jackie YING / Motoichi KURISAWA, Institute of Bioengineering and Nanotechnology, Singapore
Shlomo YITZCHAIK, The Hebrew University of Jerusalem, Israel
Nobuhiko YUI, Tokyo Medical and Dental University, Japan
Dimitrios ZEUGOLIS, National University of Ireland, Ireland
The current capability to image and manage matter at the atomic and molecular levels enabled by a number of nanoscale tools such as scanning probes, self and directed assembly, single molecule techniques, nanolithography and DNA-based technologies, coupled with advances in biomedical informatics, biophotonics, novel theory, multiscale modeling and simulation are fuelling advanced therapeutic approaches and entirely new perspectives in medicine.
Furthermore, the convergences of biomaterials, electronics and biological systems at the nanoscale not only stimulate unprecedented opportunities through the development of novel diagnosis and imaging methods and minimally invasive targeted therapies for the early detection and treatment of disease, but also offer new opportunities in regenerative medicine, pharmaceutical technology and biomolecular analysis.
The scope of this symposium, which follows from similar symposia held in previous CIMTEC conferences, is to provide a synergetic, multidisciplinary forum covering applied chemistry and physics, materials science, electronics, biochemistry and medicine to enlighten how the deeper insight into biological events and their interplay with nanotechnology may support the development of a new generation of bioresponsive materials, micro-nano-devices and molecular level approaches suited to solve relevant biomedical problems providing responses to current medical needs.
Specific areas of interest include: new and bioinspired engineered materials; multi-scale cell engineering for functional tissue regeneration and drug and gene delivery systems; design strategies for new (nano)materials and systems for medical diagnostics, nanotheranostics and neural interfaces; minimally invasive implantable devices and prostheses, bioactive functional tissue scaffolds as well as systemic interaction in the body environment including side effects, biocompatibility and biofunctionality issues.
The technical programme is complemented by the two Special Sessions "Smart Polymers for Biomedical Applications" and "Wearable and Implantable Sensors and Body Sensor Networks".
Session Topics

FO-1 Advances in biomaterials

Synthesis, constitutive behavior, bio-functionality, bio-compatibility, design, modeling, simulation
  • Electroactive, and stimuli responsive polymers, elastomers, dendrites, hydrogels, hydrocolloids
  • Shape memory polymers and alloys, smart textiles, functionalised metal alloys
  • Bioactive and resorbable ceramics and glasses, smart optical fibres
  • Mineralization processes, biomimetic materials, self-organized biomaterials
  • Nanobiomaterials, smart nanoparticles, functionalised nanotubes, nanowires, graphene, Q-dots and plasmonic structures
  • Nanostructured materials, thin films, coatings for degradable or permanent medical devices
  • Nanobiocomposites, hybrids, heterostructures
  • Surface analysis, structure/property relationships
  • Design strategies for bio-enabled materials systems
  • Therapeutic ion releasing biomaterials
  • Soft matrices for tumor models
  • Antibacterial materials

FO-2 Enabling tools

  • Biosensors, bioactuators, BioMEMS/NEMS (see also Special Session FO-9)
  • DNA/RNA technologies
  • AFM, optical tweezers, molecular probes and devices
  • Self-assembly, bioinspired processes
  • Micro/nano lithography
  • Templating, molecular imprinting
  • Surface modification techniques for bio functionalisation
  • Theory, modelling and numerical simulation of processes and devices
  • Bioprocessing technologies
  • Cell-biomaterial interaction characterization tools

FO-3 Medical diagnostics and imaging

  • Sensors (chip devices and wearables) (see also Special Session FO-9)
  • In-vitro diagnostics: microfluidics, lab-on-a-chip
  • Non invasive imaging probes and markers:
    Nanoparticles for targeted imaging
    Multimodal nanoparticles
  • Molecular imaging: MRI, FMT, PET, Tomography, etc.
  • THz technology
  • Minimally invasive implantable devices for diagnosis and imaging

FO-4 Tissue engineering and regenerative medicine

Bio-artificial skin, cardiovascular tissues, bio-artificial organs nervous and musculoskeletal system
  • Scaffolds and substrates for tissue and cell engineering
  • Cell bioengineering by multiscale manipulation
  • Bioactive signalling molecules
  • Intracellular signalling
  • Cell activation mechanisms in tissue regeneration
  • Cell printing biomaterials
  • In-situ tissue regeneration and control
  • Bioreactor technology
  • Self repair mechanisms
  • Power systems: nanorobots, EAPs, nanoengineered biofuel cells
  • Biomechanics of soft and hard tissues
  • Biofunctionality, bio compatibility and toxicological issues
  • Theory, modelling and numerical simulation
  • Biomaterials with controlled bioresorbable behavior
  • Soft matrices for cell encapsulation and delivery

FO-5 Targeted delivery, controlled release systems and nanotheranostics

  • Molecular, cellular and higher levels targeting
  • Systems for targeted delivery of drugs, peptides, proteins, growth factors, gene therapy agents and vaccines
  • Carrier materials: liposomes, micelles, dendrimers, micro/ nanocapsules, hydrogels, molecularly imprinted polymers, macromolecular conjugates, mesoporous inorganic materials
  • Drug targeting and targeting and imaging agents to site/specific delivery
  • Antibody targeting
  • Controlled release systems
  • Bioinorganics and metal ion releasing systems
  • Theranostic nanoparticles: synthesis and characterisation
  • Pharmacokinetics and pharmacodynamics
  • In-vitro and in-vivo studies and models for drug transport, absorption metabolism and retention mechanisms
  • Clinical applications
  • Biocompatibility and safety issues
  • Nanotheranostic platforms for cancer, cardiology, CNS disorders

FO-6 Materials for neural interfaces and implantable neural devices

  • Electrical neural interfaces, multi-electrode arrays
  • Optical neural interfaces
  • Neural signal sensing and processing
  • Neuromodulation (peripheral nervous system, brain)
  • Materials for neural interfaces (soft hydrogels, ECM polymers, nanotubes, nanowires, bioinspired smart nanocomposites, thin film based electrodes, functionalised optical fibres..)
  • Micro and nano surface engineering for neural devices
  • In-vitro studies
  • Neuroprosthetic devices (hearing, vision, neural disorder..)
  • Implant-nervous tissue interactions, biocompatatibility, degradability, long term functionality

FO-7 Progress in implant prosteses

Craniofacial, dental, orthopaedic, cardiovascular
  • Selection criteria for materials
  • Modelling of tissue/implant systems
  • Micromechanics of tissue/implant interface
  • Models of macromechanical behaviour of prostheses
  • Computer aided design of prostheses
  • Biofluid mechanics
  • Molecular biomechanics and simulation
  • Biomaterials degradation (interface and systemic effects; swelling and leaching, corrosion and dissolution, friction, wear, etc..)
  • Biological mechanisms of implant failure
  • In-vitro test methods
  • In-vivo implant models
  • Infection combating systems
  • Lifetime testing and simulation
  • Case studies of clinical experience

Special Session FO-8
Smart Polymers for Biomedical Applications

Special Session FO-9
Wearable and Implantable Sensors and Body Sensor Networks

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